The purpose of this white paper is to provide an overview of the advantages of the new R2G2 (Rag2/Il2rg double knockout) model with a focus on the factors that contribute to differential radiation sensitivity between the Rag2 and models with the SCID mutation.
In addition, this paper presents the results from a radiosensitivity and an immune cell profile study. Specifically, the radiosensitivity study compared the growth and survival of Envigo’s Rag2/Il2rg double knockout (R2G2) model to the NSG™ model using three different doses of radiation.
The impact of radiosensitivity on experimental design and the interpretation of the results will also be explored.
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