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Radiosensitivity of immunodeficient mouse models in oncology studies – white paper

Discover the factors that contribute to differential radiation sensitivity between the Rag2 and SCID models

The development of highly immunodeficient strains of mice has ushered in an era of advanced human cancer models.

The purpose of this white paper is to provide an overview of the advantages of the new R2G2 (Rag2/Il2rg double knockout) model with a focus on the factors that contribute to differential radiation sensitivity between the Rag2 and models with the SCID mutation.

In addition, this paper presents the results from a radiosensitivity and an immune cell profile study. Specifically, the radiosensitivity study compared the growth and survival of Envigo’s Rag2/Il2rg double knockout (R2G2) model to the NSG™ model using three different doses of radiation.

The impact of radiosensitivity on experimental design and the interpretation of the results will also be explored.

Download your copy today and:

  • Understand that not all immunodeficient mice are equal, and the inherent differences associated with each strain.
  • Discover that R2G2 mouse features a higher degree of immunodeficiency than Nude mice, and greater radioresistance than SCID strains.
  • Explore the development of highly immunodeficient strains of mice has ushered in an era of advanced human cancer models.

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